(1) the interaction between cell - matrix collagen is the main component of the extracellular matrix, as the attachment and support the growth of cells, can induce epithelial cell proliferation and differentiation and transplantation plays an important function in supporting the organs and protect the human body. Good interaction between collagen based materials with host cells and tissues, cells and tissues become part of normal physiological function. Collagen and other components in a specific arrangement with reticular structure formed of extracellular matrix. This kind of structure to anchor and support effect on cells, and provide an appropriate microenvironment for cell proliferation and growth. In the regulation of physiological or pathological mechanism, collagen organically involved in migration and metabolism of cells, so that cells more accurately play its function. Including the application of collagen in medicine: conducive to wound healing and burn repair, plastic surgery, skin and nerve growth and vascular valve surgery etc.. Studies have shown that the synthesis of collagen gel injection combined with peptide can not only in the body but also can enhance the osteogenesis in vitro; test, can improve the 3D growth of bone cells by type I collagen treated ADAMTS-1. Experimental results show the absorbable collagen sponge and human basic fibroblast growth factor recombinant combination, can promote the regeneration of rat sciatic nerve. If this can be applied to humans, will be sciatica patients.

(2) hemostasis and wound healing function of natural collagen aggregates is a good hemostatic agent, first platelet adhesion on the surface of collagen induced platelet platelet release, then began to gather and produce the final plug. The ability to make collagen platelet aggregation seems to originate from the free amino groups, especially lysine side chain amino groups, therefore, the closed side chain of collagen carboxyl, will not cause the decreased cohesion ability, but will weaken the role of collagen to plasma caking. The natural structure of collagen, especially the four stage structure developed enough, is has the basic ability of collagen condensation. With the preparation of collagen coagulation materials, such as collagen / chitosan composite membrane hemostatic properties than ordinary materials such as gelatin is much better. The test proved that trauma method using BioGHK and collagen matrix combination for the treatment of diabetic patients is very effective. As the use of collagen hemostatic agent, can be a variety of physical form of powder, flat and cavernous etc.. Compete with collagen hemostatic materials are cellulose, gelatin and fiber derivatives, the latter advantage is the price low, but a better hemostatic effect of collagen. The experiment proves that taking the collagen based on anastomat made after femoral artery puncture wound healing of high efficiency and low complication.

(3) health care function contains no other collagen protein hydroxylysine, which is rich in nutrition. Gelatin and collagen polypeptide as the degradation of collagen, also has many excellent properties. Amino acids of collagen peptide rich, high protein content, fat free, in line with the "low fat high protein food demand, a large number of studies have indicated that collagen polypeptides can be directly absorbed in the intestinal tract, peptides and amino acids are absorbed in different ways, but also has faster than amino acid peptide, low energy consumption, no saturation and various operating characteristics of non peptide competition and inhibition. Research shows that collagen can reduce blood triglyceride and cholesterol, and can increase the body of certain lack of essential trace elements, homeostasis. Cholesterol lowering is an ideal slimming food. At the same time, collagen can accelerate the formation of hemoglobin and red blood cells function, it can improve circulation, beneficial for coronary heart disease, ischemic encephalopathy. A large number of glycine in collagen, not only involved in the synthesis of collagen in the body. But the brain cells is a central inhibitory neurotransmitter, to produce a calming effect on the central nervous system, has good effects in the treatment of anxiety disorders, neurasthenia, etc.. Collagen. Food can inhibit the coagulation protein caused by gastric acid in the stomach, which is conducive to food digestion; and inhibition of gastric acid and the original enzyme secretion, can relieve pain in patients with gastric ulcer, promote gastric ulcer healing. Collagen can also be used as a health food supplement, because plasma from collagen hydroxyproline is the vehicle plasma calcium transport to bone cells, therefore, adequate intake of collagen, can to a certain extent, to ensure the normal calcium requirement, such as the lack of the principle of glue to supplement more calcium nutrition and can not be reached effect of treatment.

(4) enhance skin metabolism of protein is the main component of organism, even human skin and hair is composed of protein. In addition, the protein almost dominated the whole life activities of biology, such as digestion, metabolism, growth, proliferation, transfer information, and resistance to diseases. Are dependent on the protein to complete. Due to the structure of collagen and collagen hydrolysate and human skin collagen similar. Good compatibility. There are ionic bond, hydrogen bond. At the same time also contains a large number of hydroxyl and amino groups of collagen structure aid, these characteristics give it a great role in cosmetics. Nutrition. Collagen containing 18 amino acids. The skin layer can give the necessary nutrients, so that the skin collagen activity strengthened. Repair. Collagen and tissue around the good affinity, which has the role of tissue repair. Moisturizing. The collagen molecule contains a large number of hydrophilic groups, which has a good moisturizing effect can be achieved. To keep the skin moist. Compatibility. Collagen has the effect of regulating and stable pH value, stable foam, emulsion colloid. At the same time, as a kind of functional ingredients in cosmetics, can relieve the damage of all kinds of surface active agent, acid, alkali and other irritating substances to the skin, hair. Affinity. Collagen has a greater affinity for skin and hair on the surface of collagen protein molecules, mainly through physical adsorption and binding ability of skin and hair, rinse treatment. Affinity with the increase of molecular weight increased. The relative molecular mass of small molecules can penetrate the skin and hair cuticle, sometimes also can through the cortex, achieve the nutritional role of the skin. In addition, the collagen solution also has strong anti radiation effect. Protect the skin from sun radiation

(5) although the immune properties of collagen macromolecules due to its repetitive structure. Compared with other immunogenic protein, collagen immunogenicity is very low. Especially it to use the collagen and collagen purification form is more obvious. The original site of the main immune collagen molecules in C and N terminal region, the two region is a non helical short amino acid sequences, which is also called the "terminal peptide"; it can be in the extraction of collagen, by selective hydrolysis or removal and inactivation; only weak immunogenicity the collagen molecule three helix, not enough to cause significant rejection. Therefore. The collagen containing allograft long-term implant surface instruments can be produced only a very low immune response. Yu Hongwei collagen and fetal brain neuron (FBN) II~ after 2D implantation in rats with cerebral ischemia, after 2D, produced only a mild immune response, immune response disappeared after 6D, and CFBN in cerebral ischemia rats grew well. Can be used for cell transplantation therapy of neurological diseases. In addition, collagen and many other properties, such as biocompatibility, biodegradability, electrostatic properties, and ion binding properties, fiber properties, mechanical properties, permeability control etc..

The above contents are in domestic and international academic research summary

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